Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies
Identifieur interne : 000250 ( France/Analysis ); précédent : 000249; suivant : 000251Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies
Auteurs : Brigitte Piallat [France] ; Abdelhamid Benazzouz [France] ; Alim-Louis Benabid [France]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 1996-07.
English descriptors
Abstract
Several studies have shown that antagonists of N‐methyl‐D‐aspartate receptors provide protection of the dopaminergic nigrostriatal pathway in animal models of Parkinson's disease. Since the substantia nigra compacta receives a moderate glutamatergic innervation from the subthalamic nucleus, we tried to determine whether subthalamic nucleus lesion could prevent the toxicity of the selective dopaminergic neurotoxin 6‐hydroxydopamine (6‐OHDA). Experiments were carried out on four groups of rats. Group 1 (n= 10) received a unilateral injection of 6‐hydroxydopamine in the striatum and group 2 (n= 10) received kainic acid in the subthalamic nucleus. Group 3 (n= 10) received an injection of kainic acid in the subthalamic nucleus and 1 week later an injection of 6‐OHDA in the striatum. Group 4 (n= 5) received the same treatment but kainic acid was replaced by saline. Apomorphine induced an ipsilateral rotation in rats of groups 2 and 3 and a contralateral rotation in rats of groups 1 and 4. The number of tyrosine hydroxylase‐immunoreactive cells in the pars compacta of the substantia nigra was not significantly different between injected and non‐injected sides in rats of groups 2 and 3, but was significantly decreased on the side ipsilateral to 6‐OHDA striatal injection in rats of groups 1 and 4. These results show that subthalamic nucleus lesion provides neuroprotection of the dopaminergic nigrostriatal pathway against 6‐OHDA toxicity and opens a new way for slowing or stopping the progression of Parkinson's disease.
Url:
DOI: 10.1111/j.1460-9568.1996.tb01603.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 003165
- to stream Main, to step Curation: 002D65
- to stream Main, to step Exploration: 002136
- to stream France, to step Extraction: 000250
Links to Exploration step
ISTEX:DCFAC59007BA9B17DB0CC3E22F6A46001793F2C5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim-Louis Benabid</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DCFAC59007BA9B17DB0CC3E22F6A46001793F2C5</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1111/j.1460-9568.1996.tb01603.x</idno><idno type="url">https://api.istex.fr/document/DCFAC59007BA9B17DB0CC3E22F6A46001793F2C5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">003165</idno><idno type="wicri:Area/Main/Curation">002D65</idno><idno type="wicri:Area/Main/Exploration">002136</idno><idno type="wicri:Area/France/Extraction">000250</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies</title><author><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurobiologie Préclinique, INSERM U.318, CHU, Pavillon B, BP 217, 38043 Grenoble Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurobiologie Préclinique, INSERM U.318, CHU, Pavillon B, BP 217, 38043 Grenoble Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurobiologie Préclinique, INSERM U.318, CHU, Pavillon B, BP 217, 38043 Grenoble Cedex 09</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1996-07">1996-07</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1408">1408</biblScope><biblScope unit="page" to="1414">1414</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">DCFAC59007BA9B17DB0CC3E22F6A46001793F2C5</idno><idno type="DOI">10.1111/j.1460-9568.1996.tb01603.x</idno><idno type="ArticleID">EJN1408</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cell death</term><term>neuroprotection</term><term>substantia nigra</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have shown that antagonists of N‐methyl‐D‐aspartate receptors provide protection of the dopaminergic nigrostriatal pathway in animal models of Parkinson's disease. Since the substantia nigra compacta receives a moderate glutamatergic innervation from the subthalamic nucleus, we tried to determine whether subthalamic nucleus lesion could prevent the toxicity of the selective dopaminergic neurotoxin 6‐hydroxydopamine (6‐OHDA). Experiments were carried out on four groups of rats. Group 1 (n= 10) received a unilateral injection of 6‐hydroxydopamine in the striatum and group 2 (n= 10) received kainic acid in the subthalamic nucleus. Group 3 (n= 10) received an injection of kainic acid in the subthalamic nucleus and 1 week later an injection of 6‐OHDA in the striatum. Group 4 (n= 5) received the same treatment but kainic acid was replaced by saline. Apomorphine induced an ipsilateral rotation in rats of groups 2 and 3 and a contralateral rotation in rats of groups 1 and 4. The number of tyrosine hydroxylase‐immunoreactive cells in the pars compacta of the substantia nigra was not significantly different between injected and non‐injected sides in rats of groups 2 and 3, but was significantly decreased on the side ipsilateral to 6‐OHDA striatal injection in rats of groups 1 and 4. These results show that subthalamic nucleus lesion provides neuroprotection of the dopaminergic nigrostriatal pathway against 6‐OHDA toxicity and opens a new way for slowing or stopping the progression of Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Piallat, Brigitte" sort="Piallat, Brigitte" uniqKey="Piallat B" first="Brigitte" last="Piallat">Brigitte Piallat</name></region><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000250 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000250 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:DCFAC59007BA9B17DB0CC3E22F6A46001793F2C5
|texte= Subthalamic Nucleus Lesion in Rats Prevents Dopaminergic Nigral Neuron Degeneration After Striatal 6‐OHDA Injection: Behavioural and Immunohistochemical Studies
}}
| This area was generated with Dilib version V0.6.23. |  |